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Table 1 General characteristics of included studies

From: Comparison of oral and intravenous tranexamic acid in total hip arthroplasty: a systematic review and meta-analysis

Study (Country)

Year

Study type

Sample size O/I

Mean age O/I

Female patients O/I

Oral group intervention

Intravenous group intervention

Prophylactic antithrombotic

Transfusion trigger

Cao (China) [23]

2018

RCT

54/54

55.7/55.7

31/34

2 g of oral TXA 2 h before surgery and 4 h, 10 h, 16 h after surgery

2 g TXA 5-10 min before surgery and 6 h, 12 h, 18 h after surgery

LMWH in hospital Rivaroxaban after discharge

Hb level was < 70 g/L or 70–100 g/L with symptoms of anemia

Kayupov (America) [24]

2017

RCT

40/43

60/55

20/21

1.95 g TXA 2 h before surgery

1 g TXA before surgery

Warfarin

Hb level was < 70 g/L or 70–100 g/L with symptoms of anemia

Luo (China) [25]

2018

RCT

60/60

67.6/67.0

32/33

2 g TXA 2 h before surgery

20 mg/kg TXA 5 min before surgery

Clexane in hospital Rivaroxaban after discharge

Hb level was < 70 g/L or 70–100 g/L with symptoms of anemia

Zhao (China) [27]

2018

RCT

40/40

60.1/59.5

18/17

20 mg/kg 2 h before surgery and 3 h after surgery

15 mg/kg TXA 10 min before surgery and 3 h after surgery

Clexane in hospital Rivaroxaban after discharge

Hb level was < 70 g/L or 70–100 g/L with symptoms of anemia

Wu (China) [26]

2018

RCT

50/50

66.5/65.1

21/20

2 g of oral TXA 2 h before surgery and 3 h, 6 h after surgery

2 g TXA 10 min before surgery and 3 h, 6 h after surgery

Clexane in hospital Rivaroxaban after discharge

Hb level was < 70 g/L or 70–100 g/L with symptoms of anemia

  1. Abbreviations: O Oral tranexamic acid group, I Intravenous tranexamic acid group, TXA Tranexamic acid, Hb Hemoglobin, RCT Randomized clinical trial, LMWH Low molecular weight heparin