Study (Country) | Year | Study type | Sample size O/I | Mean age O/I | Female patients O/I | Oral group intervention | Intravenous group intervention | Prophylactic antithrombotic | Transfusion trigger |
---|---|---|---|---|---|---|---|---|---|
Cao (China) [23] | 2018 | RCT | 54/54 | 55.7/55.7 | 31/34 | 2 g of oral TXA 2 h before surgery and 4 h, 10 h, 16 h after surgery | 2 g TXA 5-10 min before surgery and 6 h, 12 h, 18 h after surgery | LMWH in hospital Rivaroxaban after discharge | Hb level was < 70 g/L or 70–100 g/L with symptoms of anemia |
Kayupov (America) [24] | 2017 | RCT | 40/43 | 60/55 | 20/21 | 1.95 g TXA 2 h before surgery | 1 g TXA before surgery | Warfarin | Hb level was < 70 g/L or 70–100 g/L with symptoms of anemia |
Luo (China) [25] | 2018 | RCT | 60/60 | 67.6/67.0 | 32/33 | 2 g TXA 2 h before surgery | 20 mg/kg TXA 5 min before surgery | Clexane in hospital Rivaroxaban after discharge | Hb level was < 70 g/L or 70–100 g/L with symptoms of anemia |
Zhao (China) [27] | 2018 | RCT | 40/40 | 60.1/59.5 | 18/17 | 20 mg/kg 2 h before surgery and 3 h after surgery | 15 mg/kg TXA 10 min before surgery and 3 h after surgery | Clexane in hospital Rivaroxaban after discharge | Hb level was < 70 g/L or 70–100 g/L with symptoms of anemia |
Wu (China) [26] | 2018 | RCT | 50/50 | 66.5/65.1 | 21/20 | 2 g of oral TXA 2 h before surgery and 3 h, 6 h after surgery | 2 g TXA 10 min before surgery and 3 h, 6 h after surgery | Clexane in hospital Rivaroxaban after discharge | Hb level was < 70 g/L or 70–100 g/L with symptoms of anemia |