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Table 1 General characteristics of included studies

From: Comparison of oral and intravenous tranexamic acid in total hip arthroplasty: a systematic review and meta-analysis

Study (Country)YearStudy typeSample size O/IMean age O/IFemale patients O/IOral group interventionIntravenous group interventionProphylactic antithromboticTransfusion trigger
Cao (China) [23]2018RCT54/5455.7/55.731/342 g of oral TXA 2 h before surgery and 4 h, 10 h, 16 h after surgery2 g TXA 5-10 min before surgery and 6 h, 12 h, 18 h after surgeryLMWH in hospital Rivaroxaban after dischargeHb level was < 70 g/L or 70–100 g/L with symptoms of anemia
Kayupov (America) [24]2017RCT40/4360/5520/211.95 g TXA 2 h before surgery1 g TXA before surgeryWarfarinHb level was < 70 g/L or 70–100 g/L with symptoms of anemia
Luo (China) [25]2018RCT60/6067.6/67.032/332 g TXA 2 h before surgery20 mg/kg TXA 5 min before surgeryClexane in hospital Rivaroxaban after dischargeHb level was < 70 g/L or 70–100 g/L with symptoms of anemia
Zhao (China) [27]2018RCT40/4060.1/59.518/1720 mg/kg 2 h before surgery and 3 h after surgery15 mg/kg TXA 10 min before surgery and 3 h after surgeryClexane in hospital Rivaroxaban after dischargeHb level was < 70 g/L or 70–100 g/L with symptoms of anemia
Wu (China) [26]2018RCT50/5066.5/65.121/202 g of oral TXA 2 h before surgery and 3 h, 6 h after surgery2 g TXA 10 min before surgery and 3 h, 6 h after surgeryClexane in hospital Rivaroxaban after dischargeHb level was < 70 g/L or 70–100 g/L with symptoms of anemia
  1. Abbreviations: O Oral tranexamic acid group, I Intravenous tranexamic acid group, TXA Tranexamic acid, Hb Hemoglobin, RCT Randomized clinical trial, LMWH Low molecular weight heparin