Table 2 Empirical antibiotic therapy (based on local epidemiology)
Type of infection | Antibioticb | Dosagea |
|---|---|---|
Early (postoperative) | Cefuroxime | 1.500 mg IV q.i.d. or 1.500 mg loading dose, followed by 6.000 mg/24 h continuous infusion |
plus | ||
Vancomycin | 20 mg/kg loading dose, followed by 30 mg/kg/24 h continuous infusion (with adjustments based on blood level monitoring) | |
In case of sepsis add | ||
Tobramycin | 7 mg/kg once daily (with adjustments based on blood level monitoring) | |
Late acute (hematogenous) | Cefuroxime | 1.500 mg IV q.i.d. or 1.500 mg loading dose, followed by 6.000 mg/24 h continuous infusion |
In case of sepsis add | ||
Tobramycin | 7 mg/kg once daily (with adjustments based on blood level monitoring) | |
Late chronic | Ceftriaxone | 2.000 mg once daily IV or 2.000 mg loading dose, followed by 2.000 mg/24 h continuous infusion |
plus | ||
Vancomycin | 20 mg/kg loading dose, followed by 30 mg/kg/24 h continuous infusion (with adjustments based on blood level monitoring) |