Skip to main content

Table 1 Randomized controlled trials comparing ALBC vs. PBC in PJI prophylaxis during total joint replacement

From: Antimicrobials in polymethylmethacrylate: from prevention to prosthetic joint infection treatment: basic principles and risk of resistance

First Author, year

Country

Study period

Antibiotic, dose (g/40 g PMMA)

Joint

n (ALBC/PBC)

PJI ALBC

n (%)

PJI PBC

n (%)

 

Comments

Josefsson et al. 1981 [43]

Sweden

1976–1978

Gentamicin, 0,5

Hip

1633 (821:812)

3 (0,37)

13 (1,60)

P < 0.01

No systemic prophylaxis in ALBC group

McQueen et al. 1990 [44]

UK

1982–1985

Cefuroxime, 1,5

Hip and knee

401 (201:200)

2 (1,00)

2 (1,00)

n. s.

No systemic prophylaxis in ALBC group

Chiu et al. 2002 [49]

China

1994–1998

Cefuroxime, 2

Knee

340 (178:162)

0 (0,00)

5 (3,09)

P  0.0238

 

Chiu et al. 2002 [49]

China

1993–2004

Vancomycin, 1

Knee

183 (93/90)

0 (0,00)

6 (7,00)

P 0.0130

 

Hinarejos et al. 2013 [46]

Spain

2005–2010

Erythromycin, 0,5/ Colistin 3 MU

Knee

2948 (1483:1465)

20 (1,35)

20 (1,37)

n. s.

Â