Positive Bacterium culture | Negative Bacterium culture | |
---|---|---|
Intravenous Preoperative | Pathogen-sensitive antibiotics | Vancomycin of 1 g |
Topical Intraoperative | Vancomycin powder of 0.5 g/Meropenem powder of 0.5 g | Vancomycin powder of 0.5 g |
Intravenous Postoperative | Pathogen-sensitive antibiotics for 2 w | Vancomycin every 12 h for 2 w |
Intra-articular Infusion Postoperative | Multi-drug-resistant bacteria, Fungi, polymicrobial infection: pathogen-sensitive antibiotics for 12–14 d | Vancomycin of 0.5 g in the morning and Meropenem of 0.5 g in the afternoon for 12–14 d |
Oral Postoperative | After the intravenous and topical antibiotic administration, Quinolones with Rifampicin, as oral switch therapy, for at least 31 d until erythrocyte sedimentation rate (ESR) and C-reactive protein continue to decrease to normal range or remain stable and are close to the normal level. |