Skip to main content

Table 2 Antibiotic treatment protocol [21]

From: Single-stage revision for chronic periprosthetic joint infection after knee and hip arthroplasties: indications and treatments

 

Positive Bacterium culture

Negative Bacterium culture

Intravenous Preoperative

Pathogen-sensitive antibiotics

Vancomycin of 1 g

Topical Intraoperative

Vancomycin powder of 0.5 g/Meropenem powder of 0.5 g

Vancomycin powder of 0.5 g

Intravenous Postoperative

Pathogen-sensitive antibiotics for 2 w

Vancomycin every 12 h for 2 w

Intra-articular Infusion Postoperative

Multi-drug-resistant bacteria, Fungi, polymicrobial infection: pathogen-sensitive antibiotics for 12–14 d

Vancomycin of 0.5 g in the morning and Meropenem of 0.5 g in the afternoon for 12–14 d

Oral Postoperative

After the intravenous and topical antibiotic administration, Quinolones with Rifampicin, as oral switch therapy, for at least 31 d until erythrocyte sedimentation rate (ESR) and C-reactive protein continue to decrease to normal range or remain stable and are close to the normal level.