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Table 3 Cases with discordant results between culture and mNGS

From: Value of mNGS in sonication fluid for the diagnosis of periprosthetic joint infection

  Preoperative aspirate
Case Age (y)/sex Diagnosis Antibiotic Prior to surgery ESR CRP Volume/feature Conventional Culture Sonication Fluid Culture Sonication mNGS WBC (cells/μL) PMN%
1 90/M THA infection Not used 17 17.1 10 ml/bloody Negative Staphylococcus aureus Staphylococcus aureus 7838 88.2
2 63/F THA infection Not used 29 2.83 5 ml/bloody Negative Negative Parvimonasmicra 7160 83.9
3 49/M THA infection Not used 47 11.5 8 ml/yellow-sticky Negative Negative Mycoplasma hominis 6380 63.8
4 79/F TKA infection Not used 16 2.8 8 ml/bloody Negative Negative Candida tropicalis 820 47.9
5 66/F TKA infection Used 8.07 65 8 ml/yellow-sticky Negative Negative Staphylococcus epidermidis 9144 75.9
6 63/M THA infection Used 58 40.2 9 ml/bloody Negative Negative Staphylococcus epidermidis 6870 83.4
7 63/M THA infection Used 58 40.2 15 ml/bloody Negative Negative Staphylococcus epidermidis& Enterococcus faecalis 6870 83.4
8 63/M TKA infection Used 65 12.3 15 ml/yellow-sticky Negative Negative Neisseria macacae&Candida parapsilosis 32925 90.3
9 89/M TKA infection Used 120 90 34 ml/purulent Negative Negative Mycoplasma hominis 26286 85.6
10 74/M TKA infection Used 16 5.62 6 ml/purulent Enterococcus faecalis Enterococcus faecalis Enterobacter cloacae 1717 62.7
11 58/F TKA aseptic failure Not used 27 8.43 10 ml/Clean Negative Staphylococcus epidermidis Staphylococcus epidermidis 186 26.8