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Table 4 Low dose (<11 mg) vs. High Dose (≥11 mg) bupivacaine

From: Postoperative outcomes of mepivacaine vs. bupivacaine in patients undergoing total joint arthroplasty with spinal anesthesia

Outcome – n (%) or Avg. ± SD

Total Hip Arthroplasty

Total Knee Arthroplasty

High Dose Bupivacaine (n=213)

Low Dose Bupivacaine (n=222)

P-Value

High Dose Bupivacaine (n=203)

Low Dose Bupivacaine (n=327)

P-Value

Avg. Dose

12.41 ± 1.12

9.76 ± 1.23

<0.001

12.19 ± 1.08

9.80 ± 1.15

<0.001

Isobaric Bupivacaine

31 (14.6)

3 (1.4)

<0.001

17 (8.4)

11 (3.4)

0.012

0-Day LOS

48 (22.5)

56 (25.2)

0.511

18 (8.9)

41 (12.5)

0.191

LOS Days

0.95 ± 0.78

0.91 ± 0.84

0.620

1.07 ± 0.73

1.09 ± 0.98

0.823

Failed SDD Attempt

20 (6.0)

6 (6.1)

0.968

13 (3.4)

4 (2.8)

0.757

Ambulated POD0

141 (66.2)

160 (72.1)

0.185

134 (66.0)

211 (64.5)

0.728

First 6-Clicks Mobility Scorea

20.29 ± 2.95

20.39 ± 2.66

0.740

20.11 ± 2.71

20.17 ± 2.76

0.822

First PT Ambulation Distance (ft)b

160.42 ± 96.02

141.07 ± 100.99

0.052

132.54 ± 100.27

133.82 ± 96.53

0.887

Urinary Retention

5 (2.3)

2 (0.9)

0.276*

2 (1.0)

4 (1.2)

1.000*

Home Discharge

206 (96.7)

214 (96.4)

0.856

195 (96.1)

318 (97.2)

0.450

30-Day Readmission

2 (0.9)

6 (2.7)

0.285*

11 (5.4)

19 (5.8)

0.850

30-Day ED Return

7 (3.3)

8 (3.6)

0.856

4 (2.0)

11 (3.4)

0.347

  1. P-Values <0.05 in bold
  2. LOS length of stay, SDD same day discharge, POD postoperative day, PT physical therapy, ED emergency department
  3. *Denotes Fisher’s Exact Test
  4. an= THA 198 High, 202 Low; TKA 195 High, 307 Low
  5. bn= THA 198 High, 197 Low; TKA 194 High, 307 Low