Table 1 Summary findings on differential leukocyte count in identifying persistent infection in patients with spacers
From: Interval between two-stage exchanges: what is optimal and how do you know?
Publication | Population | Proposed cutoff | Sensitivity | Specificity | Positive predictive value | Negative predictive value | Accuracy |
|---|---|---|---|---|---|---|---|
Shukla et al. 2010 [9] | 87 hip spacers | 3,528 cells/μL | 78% | 96% | - | - | 94% |
79% PMN | 78% | 82% | - | - | 82% | ||
Kusuma et al. 2011 [10] | 76 knee spacers | 1,102 cells/μL | 75% | 61% | - | - | 62% |
71% PMN | 75% | 66% | - | - | 66% | ||
Hoell et al. 2016 [33] | 115 spacers (56 hips and 59 knees) | 970 cells/μL | 31% | 39% | 11% | 71% | - |
- | - | - | - | - | - | ||
Newman et al. 2017 [38] | 77 hip spacers | 3,000 cells/μL | 47% | 87% | 50% | 85% | 78% |
80% PMN | 76% | 80% | 52% | 92% | 79% | ||
Zmistowski et al. 2017 [39] | 128 spacers (40 hips and 88 knees) | 1,234 cells/μL | 44% | 77% | 26% | 88% | 70% |
57% PMN | 67% | 59% | 24% | 90% | 60% | ||
Muhlhofer et al. 2018 [12] | 141 spacers (45 hips and 68 knees) | Not specified | 10% | 81% | 10% | 81% | - |
Not specified | 10% | 79% | 9% | 81% | - | ||
Boelch et al. 2018 [31] | 94 knee spacers | 4,450 cells/μL | 50% | 76% | 17% | 97% | - |
- | - | - | - | - | - | ||
Boelch et al. 2018 [32] | 92 hip spacers | 2,000 cells/μL | 25% | 97% | 67% | 82% | - |
- | - | - | - | - | - | ||
Ascione et al. 2021 [37] | 82 knee spacers | 934 cells/μL | 82% | 82% | 41% | 98% | - |
52% PMN | 82% | 78% | 36% | 97% | - |