Table 5 Comparison of the prior studies regarding procalcitonin in the diagnosis of PJI
From: Current relevance of biomarkers in diagnosis of periprosthetic joint infection: an update
Procalcitonin | Infection Definition | Cut-off (ng/mL) | Sensitivity | Specificity |
|---|---|---|---|---|
Glehr et al., CORR, 2013 [25] | MSIS 2011 | 0.35 0.75 | 90% 48% | 33% 100% |
Randau et al., 2014 [24] | 1 of the following criteria: (1) purulent synovial fluid or 1,700 leukocytes/L or 65% neutrophils in the joint aspirate (TKA) (3,600 leukocytes/L or 80% neutrophils (THA)), (2) histological confirmation of PJI, (3) pathogens detected in sterile joint aspiration or in at least two intraoperative tissue specimens, or (4) definitive signs of PJI clinically or intraoperatively (e.g., sinus tract) | 0.46 | 13% | 100% |
Klim et al., Int Orthop, 2020 [17] | MSIS 2011 | 0.1 | 40% | 90% |