Current relevance of biomarkers in diagnosis of periprosthetic joint infection: an update

Arthroplasty

Table 9 Comparison of prior studies regarding leukocyte esterase in the diagnosis of PJI

Leukocyte esterase	Infection definition	Cut-off	Sensitivity	Specificity
Parvizi et al., 2011 [42]	Own Institute^a	+ +	80%	100%
Ruangsomboon et al., 2017 [38]	ICM Criteria	+ +	94%	87%
Guenther et al., 2014 [43]	MSIS	+ +	100%	96.5%

^a Own Institutional Criteria-(1) they presented with asinus tract or an open wound in communication with the joint, (2) purulence was encountered in the joint intraoperatively, (3) cultures of fluid or tissue obtained from the joint preoperatively or intraoperatively tested positive for the presence of a pathogen, or (4) elevated serum marker levels as well an elevated white blood-cell count and/or an abnormal differential cell count were observed

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