Table 1 Hypersensitivity reactions
Mediator | Physiological function | Condition examples | |
|---|---|---|---|
Type I | IgE | Response against parasites via mast cells and basophil activation | Asthma Anaphylaxis |
Type II | IgG/IgM | Cytotoxicity—targets antigens expressed on infected cells | Heparin-induced thrombocytopenia |
Type III | Immune complex | Accumulation of antigen–antibody complex formation | Systemic lupus erythematosus |
Type IV | Cell-mediated | Four subtype activations: macrophages, eosinophils, cytotoxic CD8 + cells, neutrophils | Contact dermatitis Behcet’s disease |