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Table 2 Associations of the studied gene polymorphisms with KOA in subjects with BMI < 30 and BMI ≥ 30

From: Polymorphism rs143384 GDF5 reduces the risk of knee osteoarthritis development in obese individuals and increases the disease risk in non-obese population

Chr

SNP

Gene

Minor allele

n

Allelic model

Additive model

Dominant model

Recessive model

OR

95%CI

P

OR

95%CI

P

OR

95%CI

P

OR

95%CI

P

L95

U95

L95

U95

L95

U95

L95

U95

Individuals with BMI < 30

 1

rs2820436

LYPLAL1

A

676

0.81

0.63

1.03

0.084

0.80

0.59

1.07

0.132

0.82

0.56

1.19

0.295

0.56

0.28

1.15

0.116

 1

rs2820443

LYPLAL1

C

664

0.99

0.77

1.28

0.937

0.97

0.72

1.31

0.844

0.93

0.63

1.37

0.710

1.09

0.53

2.26

0.814

 2

rs3771501

TGFA

A

676

1.08

0.86

1.35

0.501

1.03

0.81

1.36

0.713

1.14

0.77

1.70

0.508

0.97

0.61

1.56

0.903

 12

rs1060105

SBNO1

T

678

1.04

0.80

1.36

0.752

1.08

0.80

1.47

0.616

0.96

0.65

1.42

0.848

1.85

0.88

3.88

0.103

 12

rs56116847

SBNO1

A

676

0.92

0.73

1.16

0.477

0.85

0.65

1.13

0.271

0.93

0.64

1.36

0.705

0.59

0.32

1.08

0.090

 16

rs6499244

NFAT5

A

677

1.03

0.82

1.28

0.808

1.04

0.80

1.35

0.793

1.15

0.76

1.74

0.508

0.94

0.60

1.47

0.787

 16

rs34195470

WWP2

A

674

1.07

0.85

1.33

0.562

1.15

0.88

1.51

0.308

1.16

0.75

1.78

0.505

1.26

0.80

1.98

0.314

 20

rs143384

GDF5

G

676

1.32

1.05

1.65

0.016

1.44

1.10

1.86

0.007

1.67

1.10

2.52

0.015

1.61

1.02

2.54

0.043

Individuals with BMI ≥ 30

 1

rs2820436

LYPLAL1

A

422

0.72

0.48

1.07

0.101

0.68

0.43

1.06

0.090

0.63

0.34

1.17

0.140

0.54

0.21

1.38

0.195

 1

rs2820443

LYPLAL1

C

420

0.89

0.59

1.36

0.600

0.88

0.56

1.38

0.570

1.00

0.54

1.84

1.000

0.54

0.20

1.40

0.202

 2

rs3771501

TGFA

A

421

0.87

0.59

1.27

0.467

0.85

0.56

1.30

0.448

0.74

0.38

1.45

0.384

0.88

0.42

1.85

0.730

 12

rs1060105

SBNO1

T

422

1.25

0.76

2.03

0.378

1.47

0.85

2.52

0.168

1.65

0.86

3.15

0.130

1.29

0.31

5.40

0.724

 12

rs56116847

SBNO1

A

422

0.86

0.58

1.27

0.444

0.84

0.55

1.31

0.451

0.60

0.32

1.13

0.115

1.42

0.56

3.57

0.459

 16

rs6499244

NFAT5

A

422

1.27

0.86

1.87

0.234

1.42

0.92

2.21

0.114

1.65

0.86

3.13

0.130

1.53

0.69

3.42

0.296

 16

rs34195470

WWP2

A

422

1.06

0.72

1.56

0.762

1.05

0.67

1.64

0.835

0.96

0.48

1.91

0.913

1.21

0.55

2.67

0.631

 20

rs143384

GDF5

G

422

0.85

0.58

1.25

0.415

0.78

0.50

1.21

0.263

1.03

0.54

1.95

0.940

0.41

0.20

0.94

0.019

  1. All results were obtained after adjustment for covariates
  2. OR Odds ratio, 95%CI 95% confidence interval
  3. P values < 0.05 are shown in bold
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